Little Lulu is a comic strip created in 1935 by American author Marjorie Henderson Buell. The character, Lulu Moppet, debuted in The Saturday Evening Post on February 23, 1935, in a single panel, appearing as a flower girl at a wedding and mischievously strewing the aisle with banana peels. Little Lulu replaced Carl Anderson's Henry, which had been picked up for distribution by King Features Syndicate. The Little Lulu panel continued to run weekly in The Saturday Evening Post until December 30, 1944. A later variation of the character is Little Audrey from Harveytoons.

Little Lulu was created as a result of Anderson's success. Schlesinger Library curator Kathryn Allamong Jacob wrote:

Lulu was born in 1935, when The Saturday Evening Post asked Buell to create a successor to the magazine’s Henry, Carl Anderson’s stout, mute little boy, who was moving on to national syndication. The result was Little Lulu, the resourceful, equally silent (at first) little girl whose loopy curls were reminiscent of the artist’s own as a girl. Buell explained to a reporter, "I wanted a girl because a girl could get away with more fresh stunts that in a small boy would seem boorish".